The Red Devils will enter the match off the back of a 3-0 win over Bournemouth in the Premier League on Tuesday, while Everton suffered a 4-1 defeat to Brighton & Hove Albion on the same night.
Man United were knocked out of the FA Cup in the fourth round last season by Middlesbrough, but they are the second-most successful side in the history of the competition, lifting the trophy on 12 occasions.
The Red Devils last won the FA Cup in 2016, but it does appear that Ten Hag will take every competition seriously this season, as the Dutchman bids to secure silverware in his first season at the helm.
Everton, meanwhile, are five-time winners of the FA Cup, last winning the trophy in 1995, when they recorded a 1-0 victory over Man United in the final, with Paul Rideout netting the only goal of the contest.
The Toffees have already lost to the Red Devils this season, suffering a 2-1 home defeat in the Premier League on October 9, but they have drawn their last three fixtures at Old Trafford, which should hand the Merseyside outfit confidence ahead of Friday's contest.
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