There were shocks along the way, with one Premier League club falling to lower league opposition and other mini-surprises in a couple of the all-top flight ties.
Here's your roundup of the night's Carabao Cup fixtures...
Arsenal 1-3 Brighton
Newcastle 0-0 Crystal Palace (3-2 on penalties)
Nottingham Forest 2-0 Tottenham
Southampton 1-1 Sheffield Wednesday (6-5 on penalties)
West Ham 2-2 Blackburn (9-10 on penalties)
Wolves 1-0 Leeds
Liverpool 0-0 Derby (3-2 on penalties)
Man City 2-0 Chelsea